The polyamine system in gender-related renoprotection (B05)

• Subject Area: Anatomy and Physiology ; Nephrology
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 394046635

We will investigate how changes in the polyamine system contribute to the gender-dependent susceptibility to AKI. To recognize the influence of sex-related polyamine levels on the outcome of AKI, we will expose male mice with and without gonadectomy and female mice with and without testosterone treatment to renal IRI. Polyamine production and breakdown in these animals will be blocked to explore whether gender-dependent differences in the outcome of AKI can be attenuated by pharmacologic inhibition of the polyamine system. Furthermore, murine embryonic kidney explants and zebrafish larvae will be used as screening tools to investigate how testosterone interferes with prospective drugs targeting the homeostasis of polyamines for renoprotection.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1365: Renoprotection
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Privatdozentin Dr. Karin Kirschner; Professor Dr. Holger Scholz