Transcriptional and epigenetic control of endothelial cell fate, plasticity and instructive signaling in the heart (A03)

• Subject Area: Cardiology, Angiology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 394046768

The focus of project A03 will lie on understanding the molecular determinants and the role of biomechanical stimuli in endothelial cell fate and plasticity as well as the instructive functions of distinct endothelial cell sub-populations in controlling heart structure and function. Experiments will be pursued aiming at (i) unraveling the regulatory networks governing endothelial fate and plasticity in heart development and function, (ii) underpinning the role of angiocrine signaling on cardiomyocyte proliferation and growth, contractility and rhythmicity, and (iii) characterizing the role of biomechanical forces in controlling endothelial fate and function in the heart.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1366: Vascular Control of Organ Function
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professorin Dr. Gergana Dobreva