Relevance of immigrating B-lymphocytes and their functional properties for the development of allograft nephropathy (B06)

• Subject Area: Nephrology
• Term: from 2019 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 387509280

Chronic antibody-mediated allograft rejection (ABMR) is still a main cause for the high rate of graft loss after kidney transplantation. We will study the relevance of graft-infiltrating B-lymphocytes during ABMR and the molecular mechanisms and signals involved. Our experiments will be performed using a well-established experimental transplantation model in rats and will be validated by studying human allograft biopsies. The expected results will help understand the mechanisms of ABMR and develop a new approach to the long-term suppression of donor-specific antibody formation, which could lead to a new strategy for the treatment of chronic allograft failure.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1350: Tubulussystem und Interstitium der Niere: (Patho-)Physiologie und Crosstalk
• Applicant Institution: Universität Regensburg
• Project Heads: Professor Dr. Bernhard Banas; Privatdozent Dr. Tobias Bergler; Professor Dr. Edward K. Geissler, Ph.D.