Relevance of inflammation and fibrosis for renal regeneration (B04)

• Subject Area: Nephrology ; Rheumatology
• Term: from 2019 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 387509280

Kidneys have an impressive, yet incomplete capability to regenerate after acute insults. The aim of our project is to better understand how the immune response and specific subsets of inflammatory cells as well as specific “types” of fibrosis generated by different types of collagen-producing cells support or impede regeneration of renal structures, recovery of renal function, and regression of fibrosis. We will use reversible unilateral ureteral obstruction and adenine feeding to model acute renal insults and to follow regeneration.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1350: Tubulussystem und Interstitium der Niere: (Patho-)Physiologie und Crosstalk
• Applicant Institution: Universität Regensburg
• Project Head: Professor Dr. Matthias Mack