Project Details
Projekt
Tubular and interstitial proteases as regulators of the epithelial sodium channel (ENaC) (A04)
Subject Area
Anatomy and Physiology
Nephrology
Nephrology
Term
from 2019 to 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 387509280
The appropriate regulation of the epithelial sodium channel (ENaC) in the distal nephron is essential for the fine-tuning of renal sodium excretion. In addition to tubular proteases activating ENaC by proteolytic channel cleavage, interstitial proteases may modulate ENaC activity by activating the basolateral protease-activated receptor type 2 (PAR2). This project combines electrophysiological and molecular biological methods to identify tubular proteases relevant for proteolytic ENaC activation and to investigate the molecular mechanisms involved. Moreover, the underlying mechanisms and signaling pathways of PAR2-mediated ENaC regulation by interstitial proteases will be elucidated.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Regensburg
Project Heads
Professorin Dr. Silke Härteis; Professor Dr. Christoph Korbmacher
