Mechanisms of early ciliogenesis
(A01)
Subject Area
Nephrology
Nuclear Medicine, Radiotherapy, Radiobiology
Term
from 2019 to 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 387509280
Defects in primary cilia, singular extensions of almost all mammalian cell types, give rise to a wide variety of genetic diseases, including cystic kidney disease. Despite their great importance, it is virtually unknown by what mechanisms primary cilia are formed. Our own preliminary data provide sound evidence that endocytosed plasma membrane accounts for the early stages of ciliogenesis. In order to better understand this process, the underlying form of endocytosis and the intracellular trafficking pathway from the plasma membrane to the centrosome will be characterized in detail.
DFG Programme
Collaborative Research Centres
