Influence of the short-chain fatty acid propionate as a metabolite of the human intestinal microbiome in the context of arthritic diseases.

• Applicant: Professor Dr. Mario M. Zaiss
• Subject Area: Rheumatology ; Nutritional Sciences
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 414679416

The aim of this research project is the analysis of the influence of short-chain fatty acid propionate on arthritic diseases by the modulation of T effector cells and regulatory T cells (Treg). We hypothesis that strengthening regulatory immune elements can lead to improved control and suppression of disease progression in arthritic diseases, as well as protection against bone/joint tissue destruction and subsequent loss of function.

• DFG Programme: Clinical Trials
• Co-Investigators: Dr. Axel Hueber; Privatdozent Dr. Hans-Jürgen Rech; Professor Dr. Georg Schett