Cardiac function after trauma and MSC-based regenerative strategies (C07*)

• Subject Area: Orthopaedics, Traumatology, Reconstructive Surgery ; Hematology, Oncology
• Term: from 2019 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 251293561

Cardiac dysfunction after trauma is associated with altered cardiac cell-to-cell and intracellular integrity. Furthermore, danger associated molecular patterns (DAMPs) and complement-activation products, both known to be elevated after major trauma, have been demonstrated to interact with cardiomyocytes, resulting in electrophysiological and molecular alterations and inflammation. Therefore, this project investigates whether serum components from patients with multiple trauma lead to molecular, structural, and functional alterations of cardiomyocytes in vitro. In murine blunt chest trauma, cardiac dysfunction, cardiac damage, and inflammation will be assessed and proposed to be aggravated in a combination with unilateral femur fracture and attenuated in the presence of mesenchymal stem cells (MSCs).

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1149: Danger Response, Disturbance Factors and Regenerative Potential after Acute Trauma
• Applicant Institution: Universität Ulm
• Project Heads: Professorin Dr. Miriam Kalbitz; Professor Dr. Hubert Schrezenmeier