TRPM5: a new target for the resolution of airway inflammation (P22)

• Subject Area: Anatomy and Physiology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 239283807

Our recent work indicates that TRPM5 in airway epithelial brush cells (BC) is crucial for bacterial recognition, induction of early immune responses and better outcome in Pseudomonas aeruginosa-induced pneumonia. We hypothesize that TRPM5 in BC is crucial for the initiation of innate and adaptive immune responses to pneumonia through a tight interaction with the peripheral nervous system. We aim to address the question of how TRPM5 activation or deficiency in BC influences the dendritic and innate lymphoid cell function and what the impact of TRPM5 function on TRPA1 and TRPV1 activity in sensory neurons in pneumonia is. Finally, we aim to prove whether targeting of TRPM5 in humans might offer a new therapeutic strategy to combat respiratory infections.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 152: TRiPs to Homeostasis: Maintenance of Body Homeostasis by Transient Receptor Potential Channel Modules
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professorin Dr. Gabriela Krasteva-Christ