Functional and molecular specificity of OCaR-control of intracellular Ca2+ release (P21)

• Subject Area: Pharmacology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 239283807

OCaR1 and OCaR2, two intracellularly located membrane proteins, have been established as important controllers of NAADP-mediated Ca2+ signaling. However, the Ca2+-source(s) and their specific molecular link(s) to OCaRs are not yet resolved. In our project we will resolve the molecular environment of OCaRs using affinity, proximity and organellar proteomics in cardiomyocytes, pancreatic acinar cells and platelets. This will provide insight into cell-type specificity and mechanisms of OCaR controlled Ca2+ signalling, the physiological impact of which will be functionally investigated at cellular as well as at systemic level.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 152: TRiPs to Homeostasis: Maintenance of Body Homeostasis by Transient Receptor Potential Channel Modules
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Professor Dr. Marc Freichel; Dr. Uwe Schulte, since 7/2022