Transcriptional complexes and chromatin reorganization in lineage choices and differentiation of embryonic stem cells (A16*)

• Subject Area: General Genetics and Functional Genome Biology
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 122491522

Embryonic stem (ES) cells can differentiate into virtually all somatic cell types. The establishment of cell type-specific gene expression patterns requires integrated activity of multiple factors including signaling molecules, transcription factors and epigenetic modifiers. Upon different cues, transcription factors bind cell type-specific enhancers and together with cofactors and epigenetic modifiers play key roles in epigenetic and transcriptional programming instructing the lineage choices and differentiation of embryonic stem cells. The objective of the proposed research program is to characterize the transcriptional and epigenetic events controlling cardiovascular versus hematopoietic lineage choice and cardiovascular differentiation of embryonic stem cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 873: Maintenance and Differentiation of Stem Cells in Development und Disease
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professorin Dr. Gergana Dobreva