Platelet-dependent injury and safeguard mechanisms in acute ischaemic stroke
(B02)
Subject Area
Clinical Neurology; Neurosurgery and Neuroradiology
Molecular Biology and Physiology of Neurons and Glial Cells
Term
from 2018 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 374031971
We have shown that platelets and immune cells jointly drive penumbral tissue loss and ischaemia/reperfusion injury under and after middle cerebral artery occlusion in mice, and confirmed the concept of thrombo-inflammation in the human system using local pial blood samples obtained directly from the cerebral collateral circulation. As next steps we will characterise the contribution of platelet-derived DAMPs and platelet-dependent neutrophil effects on stroke development and collateral blood flow in a tandem experimental/human approach.
DFG Programme
CRC/Transregios
