Proteolytic generation of the soluble interleukin-6 receptor in vivo
(A14*)
Subject Area
Biochemistry
Term
from 2018 to 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 125440785
The project deals with the soluble IL-6R in the circulation. This protein is generated by ADAM17-independent proteolysis since humans and mice without detectable ADAM17 activity exhibit normal soluble IL-6R levels. The level of soluble IL-6R is a critical determinant of susceptibility to inflammatory diseases. The project will identify the proteolytic activity responsible for the generation of the steady-state soluble IL-6R serum levels. We will screen candidate proteases and validate their involvement in sIL-6R generation with corresponding knock-out mouse models.
DFG Programme
Collaborative Research Centres
