Homeostatic presynaptic plasticity in memory consolidation and sleep of the aging brain (A08)

Subject Area Experimental and Theoretical Network Neuroscience
Term since 2018
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 327654276
 

Project Description

Plastic processes promote memory processes by driving synapses away from equilibrium, while homeostatic plasticity resets them. Sleep is considered key for resetting, but is also involved in memory consolidation, and changes with age. In Drosophila brains we described a homeostatic form of presynaptic plasticity (PreScale) connecting sleep deprivation, homeostatic sleep drive and memory consolidation. We here address the circuit implementation of PreScale and study the protective effects of PreScale at physiological and biochemical levels. Our results will deepen our understanding of how presynaptic plasticity operates between sleep, memory consolidation and aging.
DFG Programme Collaborative Research Centres
Subproject of SFB 1315:  Mechanisms and disturbances in memory consolidation: From synapses to systems
Applicant Institution Humboldt-Universität zu Berlin
Project Head Professor Dr. Stephan J. Sigrist