Structure and dynamics of the NPC permeability barrier (B11*)

• Subject Area: Structural Biology
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 105286809

Nuclear pore complexes (NPCs) conduct nucleocytoplasmic transport through a selective permeability barrier formed by cohesive and intrinsically disordered FG repeat domains. Through a combined analysis by crystallography, biophysical characterization, and NMR spectroscopy, we will investigate the structure and dynamics of barrier-forming units as well as the detailed mechanisms of sieving and privileged nuclear transport receptor passage. Thereby we wish to understand the biophysical determinants of effective transport.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 860: Integrative Structural Biology of Dynamic Macromolecular Assemblies
• Applicant Institution: Georg-August-Universität Göttingen
• Project Heads: Dr. Loren Andreas; Professor Dr. Dirk Görlich