Role of ubiquitin networks in NF-κB driven B cell neoplasms (P06)

Activation of NF-κB is regulated by signalling cascades that depend on protein phosphorylation and activities of the ubiquitin system. We identified the ubiquitin ligases KBTBD7, KLHL21 and FBXO41 as candidates that mediate NF-κB activation in ABC-type DLBCL and found BCMA, an NF-κB activator and target for cellular immunotherapies in multiple myeloma (MM), to be regulated by the ubiquitin proteasome system (UPS). This project will strive to obtain a holistic mechanistic understanding of how ubiquitin ligases sustain NF-κB activity in DLBCL, how the UPS can direct BCMA activity and expression in MM and how these insights can forward novel actionable therapeutic targets.

DFG Programme Collaborative Research Centres

Subproject of SFB 1335:  Aberrant Immune Signals in Cancer

Applicant Institution Technische Universität München (TUM)

Project Head Professor Dr. Florian Bassermann