Project Details
Projekt
Aberrant Immune Receptor Signalling in T-cell lymphoma (P01)
Subject Area
Hematology, Oncology
Immunology
Immunology
Term
from 2018 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 360372040
T-cell non-Hodgkin lymphomas (T-NHLs) represent a group of highly aggressive cancers that are mostly incurable. Their molecular pathogenesis is still poorly defined. Recent genomic analyses have revealed numerous oncogenic alterations within T-cell antigen receptor (TCR) signalling pathways as a hallmark of T-NHLs. Furthermore, we identified PDCD-1 as a key tumour suppressor in T-cell malignancy. Here we plan to use tractable mouse models of human T-NHL to dissect the mechanisms and effects of pathologically altered T-cell receptor and coreceptor signalling in T-NHL pathogenesis and define the pro- and antilymphomagenic immune signals in these cancers.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1335:
Aberrant Immune Signals in Cancer
Applicant Institution
Technische Universität München (TUM)
Project Head
Professor Dr. Jürgen Ruland
