Project Details
Projekt
Purinergic modulation in inflammation-induced neurodegeneration (A16)
Subject Area
Molecular and Cellular Neurology and Neuropathology
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 335447717
Multiple sclerosis (MS) is the most frequent inflammatory disease of the central nervous system (CNS) also resulting in olfactory deficits. However, underlying mechanisms are not understood. The adenine nucleotide axis has a crucial role in regulation of neuro-glia communication and inflammation and thereby qualifies as an attractive switchboard for both. Using the EAE inflammation model we aim to profile the cellular vulnerability and molecular determinants of neurodegeneration in the olfactory bulb and to elucidate the role of the P2Y1R and related P2 receptors in astrocyte-neuron interaction under homeostatic and inflammatory conditions and test their neuroprotective therapeutic potential.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Hamburg
Project Heads
Professor Dr. Manuel A. Friese; Dr. Daniela Hirnet
