Astrocytic and neuronal cAMP signaling in neuroinflammation (A07)

Subject Area Molecular and Cellular Neurology and Neuropathology
Term since 2018
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 335447717
 

Project Description

We will investigate astrocyte-neuron and neuron-neuron communication downstream of cAMP signaling, and its role in hippocampal signaling deficits in murine experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. By imaging cAMP signals using genetically encoded cAMP indicators we will characterize receptor-mediated cAMP signaling in astrocytes of healthy and EAE mice. Using the photoactivatable adenylate cyclase PACmn, the role of increased cAMP on astrocyte physiology and astrocyte-dependent regulation of EAE, immediate early genes and synaptic plasticity will be tested.
DFG Programme Collaborative Research Centres
Subproject of SFB 1328:  Adenine Nucleotides in Immunity and Inflammation
Applicant Institution Universität Hamburg
Project Heads Christine Elizabeth Gee, Ph.D.; Professor Dr. Christian Lohr