Astrocytic and neuronal cAMP signaling in neuroinflammation
(A07)
Subject Area
Molecular and Cellular Neurology and Neuropathology
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 335447717
We will investigate astrocyte-neuron and neuron-neuron communication downstream of cAMP signaling, and its role in hippocampal signaling deficits in murine experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. By imaging cAMP signals using genetically encoded cAMP indicators we will characterize receptor-mediated cAMP signaling in astrocytes of healthy and EAE mice. Using the photoactivatable adenylate cyclase PACmn, the role of increased cAMP on astrocyte physiology and astrocyte-dependent regulation of EAE, immediate early genes and synaptic plasticity will be tested.
DFG Programme
Collaborative Research Centres
