Phenotypic, genetic, and transcriptional dissection of type I interferonopathies – a systems approach (B21)

• Subject Area: Human Genetics ; Pediatric and Adolescent Medicine
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 369799452

Using a systems immunology approach, we propose to dissect molecular mechanisms driving alterations in cell-type composition and dysregulation of transcriptional networks in peripheral blood mononuclear cells of patients with early-onset type I IFN-driven autoinflammation and autoimmunity at the single-cell level. The expected results will provide novel insight into disease mechanisms and will pinpoint pathways and molecules that can be exploited for the development of improved diagnosis and targeted therapeutic strategies.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 237: Nucleic Acid Immunity
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Professorin Johanna Klughammer, Ph.D.; Professorin Dr. Min Ae Lee-Kirsch