Project Details
Projekt
Sex hormones in STING-mediated nucleic acid recognition (B16)
Subject Area
Immunology
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 369799452
We have uncovered that nucleic acid immunity via cGAS/STING promotes autoimmune vasculitis using a novel pre-clinical model and independent patient cohorts. During those studies, we also found that STING activity was highly variable amongst females depending on progesterone levels. In collaboration with other TRR 237 members, our overarching goal is now to understand how sex hormones regulate STING-mediated nucleic acid immunity in autoimmune disease and anti-viral responses. Our results will contribute to expand the emerging concept of sexual dimorphism in immunity to encompass the impact of the hormonal stage (reproductive cycle, age) on STING-mediated responses.
DFG Programme
CRC/Transregios
Subproject of
TRR 237:
Nucleic Acid Immunity
Applicant Institution
Ludwig-Maximilians-Universität München
Project Heads
Professor Dr. Natalio Garbi; Dr. Lino Lars Teichmann, until 12/2022
