Contribution of cellular stress to RNA virus PAMP recognition (A12)

• Subject Area: Virology ; Immunology
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 369799452

This project addresses the fundamental question how persistent RNA viruses can go unrecognized by the innate immune system. The analysis of isogenic persistent and acute rabies rhabdoviruses provided experimental evidence for contribution of cellular stress sensors to virus PAMP recognition and induction of an antiviral response. Upon determination of the stress types involved it will be determined whether stress can prime RLR sensors for better recognition of viral RNA, or whether endogenous danger signals (DAMPs) are produced that synergize with viral RNA in cell activation.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 237: Nucleic Acid Immunity
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Professor Dr. Karl-Klaus Conzelmann