DNA damage response signaling mediated antiviral response (A09)

• Subject Area: Immunology
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 369799452

DNA damage response (DDR) cascades entail networks of pathways that signal upon the detection of respective lesions to initiate processes geared at the restoration of genomic integrity. At the same time a plethora of antiviral transcripts are induced in the context of DDR, which implies a direct or indirect connection of these pathways to antiviral sensing or defense. Here, we want to elucidate under what circumstances this antiviral DDR response pathway is triggered, map the underlying signal transduction cascade and characterize how it diverges or overlaps with canonical pattern recognition receptor pathways leading to antiviral immune responses.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 237: Nucleic Acid Immunity
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Professor Dr. Veit Hornung