Dissecting Toll-like receptor 3 function in pancreatic regeneration and neoplastic transformation
(P05)
Subject Area
Gastroenterology
Term
from 2018 to 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 329628492
The Toll-like receptor (TLR) pathways are frequently altered at the genetic level in PDAC. Based on this and our own preliminary work, which shows a defective pancreatic regeneration and pronounced Kras-driven inflammation in the context of TLR3 loss, we hypothesize that the nucleic acid sensor TLR3 plays an essential and compartment-specific role during regeneration and carcinogenesis in the pancreas. In this research initiative, we aim to dissect the specific role of TLR3 in these processes. The overall aim is to identify new druggable pathways that critically influence pancreatic tumorigenesis.
DFG Programme
Collaborative Research Centres
