Multiscale functional mapping of cell identity decisions in PDAC initiation (P01)

• Subject Area: Gastroenterology
• Term: from 2018 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 329628492

Pancreatic cancer evolution is characterized by consecutive cellular fate changes through molecular reprogramming. Our understanding of these processes is, however, fragmented. Utilizing unique human cellular model systems and novel screening technologies in mice, this project will chart and functionalize KRAS induced transcriptional, epigenetic and topological changes to create global maps of molecular programs driving early oncogenic cell state transitions. Integrative analyses will focus on the discovery of core transcription factor networks, followed downstream mechanistic studies on critical players, such as Foxp1, a newly identified driver of acinar to ductal metaplasia. The project has potential implications for disease prevention and therapy.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1321: Modelling and Targeting Pancreatic Cancer
• Applicant Institution: Technische Universität München (TUM)
• Project Heads: Professorin Alessandra Moretti, Ph.D.; Professor Dr. Roland Rad