Oxidative lesions of modified nucleotide bases (C03)

• Subject Area: Theoretical Chemistry: Electronic Structure, Dynamics, Simulation
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 325871075

Alkylated derivatives of cytosine, uracil and adenine important in the epigentic regulation of DNA will be synthesized in their 15N-labeled form. For all substrates pKa values will be determined employing a combined experimental/computational protocol. The ambient air oxidation of all substrates will subsequently be studied in controlled ozone-spiked environments in order to validated the initiation of the autoxidation process through this air pollutant.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1309: Chemical Biology of Epigenetic Modifications
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Hendrik Zipse