Genetic code expansion tools to introduce post-translational modifications (C02)

Subject Area Biochemistry
Term from 2018 to 2022
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 325871075
 

Project Description

Protein post-translational modifications (PTMs) are important for regulating diverse aspects of cellular physiology. Within this CRC we want to leverage genetic code expansion approaches - in conjunction with in vivo chemistries and enzymatic reactions – to site-specifically incorporate PTMs such as succinylation and ubiquitination into proteins in vivo. Such approaches will help us deciphering their roles – in collaboration with other groups of this CRC and in the Munich area – in nucleosome dynamics, DNA replication and transcription and protein localization. Furthermore these tools will benefit from the advantage of being generally applicable to diverse biological questions.
DFG Programme Collaborative Research Centres
Subproject of SFB 1309:  Chemical Biology of Epigenetic Modifications
Applicant Institution Ludwig-Maximilians-Universität München
Project Head Professorin Dr. Kathrin Lang