Dynamics of epigenetic protein modifications and RNA interactions (B02)

• Subject Area: Biochemistry
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 325871075

In this project, we ask the question if post-synthetic modifications influence the interaction of proteins with RNA to modulate their function. During the first funding period, we characterized the target and substrate spectrum of histone deacetylase (HDAC) inhibitors. We will now use these inhibitors as tools to screen for proteins that change their interaction with RNA when acetylated and investigate how this change occurs on the level of RNA-binding regions.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1309: Chemical Biology of Epigenetic Modifications
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Bernhard Küster