Effects of posttranscriptional chemical modifications on RNA structure, dynamics and protein recognition (A02)

• Subject Area: Structural Biology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 325871075

The molecular, structural and functional consequences of chemical RNA modifications involving adenosine-to-inosine (A-to-I) editing and m6A RNA methylation are studied. Using biochemical methods, solution-state NMR and complementary techniques the effects of A-to-I-editing and base m6A methylation on the conformation, internal dynamics and molecular interactions will be studied. The results will provide unprecedented insight and high-resolution structural information for the effects of chemical modifications of eukaryotic RNAs with important functions in posttranscriptional gene regulation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1309: Chemical Biology of Epigenetic Modifications
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Michael Sattler