Project Details
Projekt
Treatment options for chronic hyponatremia and their effects on bone tissue and bone healing in the rat osteopenia model
Applicants
Dr. Marina Komrakova; Professor Dr. Stephan Sehmisch
Subject Area
Orthopaedics, Traumatology, Reconstructive Surgery
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 401760883
Hyponatremia (HypoNa) is the most common electrolyte disorder encountered in the clinical practice. Stable, mild chronic HypoNa is generally considered asymptomatic when using typical clinical criteria. In many patients with HypoNa secondary to medications, physicians generally tolerate the presence of mild HypoNa. However, mild chronic HypoNa is also associated with poor clinical outcome, increased risk of falls with associated fragility fractures, increased length of hospital stay and mortality. Preclinical and clinical studies showed that chronic HypoNa can cause or accelerate osteoporosis. Osteoporosis leads to a high incidence of bone fractures which is associated with substantial morbidity and mortality in patients. Bone fractures in the osteoporotic patient represent a challenge to the surgeon. Osteoporosis complicates both fracture treatment and healing. In our previous study, we observed that both estrogen deficiency known to be the cause for development of postmenopausal osteoporosis and HypoNa impaired bone healing and the combination of these two factors had synergetic detrimental effect on bone. The intention of the present study is to characterize bone tissue and bone healing after HypoNa correction using several methods applied in the clinics. The effectiveness of these methods of HypoNa correction on bone tissue will be compared. Possible side effects will be documented. There is no data on this matter so far. HypoNa will be induced using an established method of treatment with antidiuretic hormone in ovariectomized rats. One of the most common causes of chronic HypoNa is the Syndrome of inappropriate antidiuretic hormone secretion. Inappropriate vasopressin release is usually caused by various diseases, drugs or other reasons. The findings of the study may show up a perspective for therapeutic treatment of chronic HypoNa in fracture patients which may improve fracture healing and the quality of life.
DFG Programme
Research Grants
