Development of a novel glioma-specific therapeutic and imaging agent.

• Applicant: Dr. Niklas von Spreckelsen
• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology
• Term: from 2018 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 400975596

• Final Report Year: 2020

Final Report Abstract

Given the dim prognosis and unique challenges throughout the clinical course, new approaches to GBM therapy and diagnostics are desperately needed. In our work we detailed first steps towards a peptide (more specifically BTP-7) based therapy and PET-imaging. While more studies and optimization are needed to eventually complete clinical translation, we have shown that BTP-7 is a viable candidate to further advance the treatment/imaging of GBM.

Publications

• A Platinum(IV) Prodrug—Perfluoroaryl Macrocyclic Peptide Conjugate Enhances Platinum Uptake in the Brain. Journal of Medicinal Chemistry 2020 63 (13), 6741-6747
  Colin M. Fadzen, Justin M. Wolfe, Wen Zhou, Choi-Fong Cho, Niklas von Spreckelsen, Kathryn T. Hutchinson, Yen-Chun Lee, E. Antonio Chiocca, Sean E. Lawler, Omer H. Yilmaz, Stephen J. Lippard, and Bradley L. Pentelute
  (See online at https://doi.org/10.1021/acs.jmedchem.0c00022)
• BTP-7, a novel peptide for therapeutic targeting of malignant brain tumors
  Niklas von Spreckelsen, Yarah Ghotmi, Colin M. Fadzen, Justin M. Wolfe, Nina Hartrampf, Charlotte Farquhar, Sonja Bergmann, Mykola Zdioruk, J. Roscoe Wasserburg, Emily Murrell, Fernanda C. Bononi, Leonard G. Luyt, Martine L. M. Lamfers, Keith L. Ligon, E. Antonio Chiocca, Mariano S. Viapiano, Bradley L. Pentelute, Sean E. Lawler, Choi-Fong Cho
  (See online at https://doi.org/10.1101/2020.05.21.106633)
• Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus. Molecular Cell, Volume 78, Issue 6,2020, Pages 1207-1223.e8
  Marco Mineo, Shawn M. Lyons, Mykola Zdioruk, Niklas von Spreckelsen, Ruben Ferrer- Luna, Hirotaka Ito, Quazim A. Alayo, Prakash Kharel, Alexandra Giantini Larsen, William Y. Fan, Sophia Auduong, Korneel Grauwet, Carmela Passaro, Jasneet K. Khalsa, Khalid Shah, David A. Reardon, Keith L. Ligon, Rameen Beroukhim, Hiroshi Nakashima, Pavel Ivanov, Paul J. Anderson, Sean E. Lawler, E. Antonio Chiocca
  (See online at https://doi.org/10.1016/j.molcel.2020.05.015)