pH-switchable shark-derived single domain antibodies for biomedical applications

• Applicant: Professor Dr. Harald Kolmar
• Subject Area: Biochemistry
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 398463564

• Final Report Year: 2022

Final Report Abstract

No abstract available

Publications

• Dual Function pH Responsive Bispecific Antibodies for Tumor Targeting and Antigen Depletion in Plasma. Frontiers Immunol (2019)
  Bogen, J.P., Hinz, S.C., Grzeschik, J., Ebenig, A., Krah, S., Zielonka, S., Kolmar, H.
  (See online at https://doi.org/10.3389/fimmu.2019.01892)
• A Generic Procedure for the Isolation of pH- and Magnesium-Responsive Chicken scFvs for Downstream Purification of Human Antibodies. Front Bioeng Biotechnol 8:688 (2020)
  Hinz, S.C., Elter, A., Rammo, O., Schwämmle, A., Ali, A., Zielonka, S., Herget, T. & Kolmar, H.
  (See online at https://doi.org/10.3389/fbioe.2020.00688)
• Protease-Activation of Fc-Masked Therapeutic Antibodies to Alleviate Off-Tumor Cytotoxicity. Front Immunol 12, 715719 (2021)
  Elter, A., Yanakieva, D., Fiebig, D., Hallstein, K., Becker, S., Betz, U., Kolmar, H.
  (See online at https://doi.org/10.3389/fimmu.2021.715719)