Predicting evolutionary pathways to β-lactam resistance (A02)

• Subject Area: Evolutionary Cell and Developmental Biology (Zoology)
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 325931972

focuses on the evolution of resistance against β-lactams, an important class of antibiotics. We will map cost and benefit of resistance and predict adaptive trajectories of resistance evolution as a function of drug concentration and population size. These predictions will be tested in massively parallel evolution experiments. The overarching goal of the project is an integrated understanding of genetic and environmental constraints contributing to the evolution of resistance to a specific class of commonly used drugs.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1310: Predictability in Evolution
• International Connection: Netherlands
• Applicant Institution: Universität zu Köln
• Project Heads: Professor Dr. Joachim Krug; Professor Dr. Arjan G.M. de Visser