Analysis of tumor dormancy and progression in biofabricated vascularized 3D models (C03)

• Subject Area: Hematology, Oncology ; Biomaterials ; Cell Biology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 326998133

The aim of the second funding period is the in vitro biofabrication of in vivo tumor models as well as in vivo evaluation of tumor models in the vascularized AV loop model. The primary focus will be the evaluation of tumor dormancy and progression and the influence of the tumor microenvironment. Based on our previous studies, more complex tumor models will be biofabricated using different areas, stiffnesses and cell types and the tumor cell behavior will be analyzed also on molecular level.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 225: From the fundamentals of biofabrication towards functional tissue models
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Professor Dr. Andreas Arkudas; Professorin Dr. Anja-Katrin Bosserhoff; Privatdozentin Dr. Annika Kengelbach-Weigand