The role of local tumor barrier function for tumor cell plasticity, invasion and metastasis of colorectal cancer (C11*)

• Subject Area: Gastroenterology ; Hematology, Oncology
• Term: from 2018 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 89986987

Previous work of the applicants had shown that the microbiome emerged as a major regulator of colorectal carcinogenesis. To understand this interaction in more detail, they will explore how the tumor barrier functionality and the microbiota are involved in the regulation of EMT and metastasis formation in colorectal cancer. Thus, they will analyze the impact of infiltrating immune cells and the gut flora on both the tumor microenvironment and tumor cell intrinsic signaling events to understand the initiation of pre-metastatic niche formation that leads to EMT and metastasis in colorectal cancer.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 850: Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Professor Dr. Stefan Fichtner-Feigl; Privatdozentin Dr. Rebecca Kesselring