Integrated Co-clinical Analysis of 3-D Tumor Organoids to Target Invasion and Metastasis in Pancreatic Cancer (C09*)

Subject Area Hematology, Oncology
Cell Biology
Term from 2018 to 2021
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 89986987
 

Project Description

The applicants will exploit a unique and continuously growing collection of 3-D tumor organoids derived from patients undergoing treatment for pancreatic ductal adenocarcinoma (PDAC). The goal of the project is to identify and validate potential biomarkers and therapeutic target structures of the migratory, invasive and metastatic capacity of individual patient-derived tumors based on a combined comprehensive molecular and ex vivo co-clinical functional analysis.
DFG Programme Collaborative Research Centres
Subproject of SFB 850:  Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis
Applicant Institution Albert-Ludwigs-Universität Freiburg
Project Heads Professorin Dr. Melanie Börries; Dr. Ralph Fritsch