Project Details
Projekt
Effects of genetic Raf kinase inhibitor protein (RKIP), RAAS and eNOS modulation on adverse cardiovascular remodeling and senescence in CKD (M06)
Subject Area
Cardiology, Angiology
Term
from 2018 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939
We recently discovered that 129/Sv mice are highly susceptible to myocardial maladaptive remodeling in CKD. Based on these findings, this project aims to pinpoint the effects of RAAS and eNOS signaling in cardiac remodeling and senescence in CKD and the cell type-specific role of RKIP, with the overall goal to better understand the mechanisms of CKD-induced myocardial fibrosis and identify possible future targets for prevention or therapy.
DFG Programme
CRC/Transregios
Applicant Institution
Rheinisch-Westfälische Technische Hochschule Aachen
Project Head
Dr. Christian Werner
