Modulatory effects of SGLT2 inhibition on cardiac metabolism in CKD patients (M03)

• Subject Area: Cardiology, Angiology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939

CKD induces processes of accelerated aging in the heart, termed uremic cardiomyopathy (UC), leading to cellular senescence, degeneration and fibrosis by yet incompletely understood mechanisms. This projects will investigate altered cardiac metabolism in CKD: it aims to decipher the underlying metabolic pathways leading to altered cardiac substrate utilization in CKD and will investigate the cardioprotective mechanisms of SGLT2 inhibition in CKD.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 219: Mechanisms of Cardiovascular Complications in Chronic Kidney Disease
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Professor Dr. Michael Lehrke; Professor Dr. Nikolaus Albert Helmut Marx