Role of interleukin-1α in CKD-associated cardiovascular complications (C09)

• Subject Area: Anatomy and Physiology
• Term: from 2018 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939

We recently identified that lipoproteins from CKD patients enhance IL-1α release from monocytes. It is suggested that IL-1α represents a key alarmin, thereby initiating systemic inflammation. We hypothesize that IL-1α plays an important role in CKD-associated systemic inflammation contributing to CKD-related cardiovascular complications. This project aims to examine how alterations of lipoproteins in CKD modulate IL-1α production/secretion in a translational study design. Also, we will investigate the role of IL-1α in crucial processes underlying the development of CKD-associated CVD.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 219: Mechanisms of Cardiovascular Complications in Chronic Kidney Disease
• Applicant Institution: Universität des Saarlandes
• Project Heads: Professorin Barbara Anne Niemeyer, Ph.D.; Professor Thimoteus Speer, Ph.D., since 4/2020; Dr. Stephen Zewinger, until 4/2020