Role of hematopoietic reprogramming in cardiorenal diseases (C08)

• Subject Area: Nephrology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939

Inflammation represents a crucial mediator of CKD and CVD alike. Our recent findings underscore the relevance of inflammation in CKD-associated CVD by engaging a specific innate immune pathway, i.e. by NLRP3 inflammasome activation. This project aims to gain novel pathophysiological insights into the effects of CKD and CVD on the hematopoietic compartment and the regulation of hematopoiesis in general. The results obtained should improve the understanding of cardiorenal disease mechanisms and identify novel anti-inflammatory treatment approaches to halt the progression of CKD and the development of its associated cardiovascular complications.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 219: Mechanisms of Cardiovascular Complications in Chronic Kidney Disease
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Professor Dr. Danilo Fliser, until 12/2021; Professor Thimoteus Speer, Ph.D.