Characterization and validation of mediators affecting myocardial infarction and vascular calcification in CKD (C04)

• Subject Area: Biochemistry
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939

We recently contributed towards the elucidation of the vascular calcification process via the detailed functional characterization of two previously identified calcification inhibitors, as well as the identification of two novel calcification mediators from hemofiltrate of CKD patients. This project will now provide deeper insight into the cardiovascular protective effects of the identified mediators in the context of myocardial infarction and vascular calcification. Also, it will study post-translational modifications (PTMs) in CKD and novel strategies to limit PTM-associated pathological changes, stimulating new therapeutic approaches to tackle increased cardiovascular risk in CKD patients.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 219: Mechanisms of Cardiovascular Complications in Chronic Kidney Disease
• Major Instrumentation: HPLC-machine
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Head: Professor Dr. Joachim Jankowski