Regulation of the immune balance during allogeneic hematopoietic stem cell transplantation (HSCT) by vitamin D3 (B12)

• Subject Area: Hematology, Oncology ; Immunology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 324392634

To understand the underlying mechanisms for the protective effects of vitamin D3 in allogeneic HSCT patients we will investigate vitamin D3-related changes in the microbiome, epithelial barrier function and immune cell infiltration in GvHD target tissues in murine GvHD models. For this purpose we will selectively delete the vitamin D3 receptor (VDR) in murine immune cells and/or epithelial cells using the Cre-lox technology and for in vitro analyses in human immune cells by CRISPR/Cas9 technology. Finally, potential mechanisms of action will be verified in human GvHD samples. Results promises to provide the basis for vitamin D3 supplementation of allo-HSCT patients in a prospective clinical trial.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 221: Modulation of graft-versus-host and graft-versus-leukemia immune responses after allogeneic stem cell transplantation
• Applicant Institution: Universität Regensburg
• Project Heads: Dr. Heiko Bruns; Professorin Dr. Marina P. Kreutz; Dr. Katrin Peter, until 12/2021