Harnessing tissue homeostasis-promoting functions of specialized regulatory T cells in graft-versus-host disease (B08)

• Subject Area: Immunology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 324392634

Regulatory T cells (Treg) perform two distinct functions: they maintain self-tolerance and support tissue-repair and organ homeostasis by differentiation into specialized tissue Treg cells. We aim to harness the tissue-repair function of tissue-Treg cells to prevent or treat graft-versus-host disease after allogeneic bone marrow transplantation. In this respect, we want to identify tissue-repair factors and will engineer and study ‘tissue smart’ Treg cells for the therapy of GvHD. We will translate these findings to human Treg cells to establish novel Treg cell therapy formats.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 221: Modulation of graft-versus-host and graft-versus-leukemia immune responses after allogeneic stem cell transplantation
• Applicant Institution: Universität Regensburg
• Project Head: Professor Dr. Markus Feuerer