Aldehyde dehydrogenase 3A2 (ALDH3A2) as a novel regulator of inflammation and fibrotic tissue remodeling in sclerodermatous chronic graft-versus-host disease
(B04)
Subject Area
Rheumatology
Hematology, Oncology
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 324392634
Metabolic deregulation is emerging as a common pathogenic driver of chronic inflammatory as well as fibrosing diseases. We demonstrated that the inactivation of aldehyde dehydrogenase 3A2 (ALDH3A2) prevented fibroblast activation and ameliorated tissue remodeling in experimental sclerodermatous chronic GvHD (sclGvHD), whereas overexpression of ALDH3A2 promoted collagen release and deposition of extracellular matrix. We now aim to decipher the molecular mechanisms underlying the effects of ALDH3A2 on fibroblast activation in sclGvHD with a focus on metabolic changes and evaluate the effects of ALDH3A2 knockdown on leukocyte infiltration and graft-versus-leukemia reaction.
DFG Programme
CRC/Transregios
