Manipulation of the kinetochore-microtubule interface by supramolecular ligands (B07)

• Subject Area: Cell Biology
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 229838028

Error-free propagation of the genome from one cell generation to the next relies on kinetochores, large protein complexes that establish controlled interactions between chromosomes and the microtubule cytoskeleton. In this project part we use supramolecular chemistry to reconstitute multivalent kinetochore-microtubule attachments in vitro and specifically perturb their function using tailored chemical compounds. These strategies will facilitate a mechanistic analysis of force generation, microtubule-dynamics control and attachment-sensing by kinetochores.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1093: Supramolecular Chemistry on Proteins
• Applicant Institution: Universität Duisburg-Essen
• Project Head: Professor Dr. Stefan Westermann