Manipulation of the kinetochore-microtubule interface by supramolecular ligands
(B07)
Subject Area
Cell Biology
Term
from 2018 to 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 229838028
Error-free propagation of the genome from one cell generation to the next relies on kinetochores, large protein complexes that establish controlled interactions between chromosomes and the microtubule cytoskeleton. In this project part we use supramolecular chemistry to reconstitute multivalent kinetochore-microtubule attachments in vitro and specifically perturb their function using tailored chemical compounds. These strategies will facilitate a mechanistic analysis of force generation, microtubule-dynamics control and attachment-sensing by kinetochores.
DFG Programme
Collaborative Research Centres
