Precision macromolecules for the sequence-controlled presentation of supramolecular ligands
(A11+)
Subject Area
Preparatory and Physical Chemistry of Polymers
Term
from 2018 to 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 229838028
We will apply sequence-controlled oligo(amidoamines) as a new platform for the multivalent presentation of non-natural supramolecular binding motifs (A1, A2, A3) in combination with biological ligands and sensor molecules (A10). The resulting macromolecular ligands will be analyzed for their modulation of different proteins such as the N-D1 interface of p97 (B2), 14-3-3 protein (B4), Survivin and Taspase1 (B5), mitotic regulators (B6) and Ndc80-microtubule interactions (B7).
DFG Programme
Collaborative Research Centres
