Spatiotemporal regulation of secretory lysosome trafficking controls epithelial tube fusion (B10)

• Subject Area: Developmental Biology
• Term: from 2018 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 386797833

This proposal investigates the mechanism of luminal plasma membrane fusion using a combination of genetic, live imaging, and biophysical approaches. We will focus on the role of secretory lysosomes (SLs), in particular addressing how they deliver membrane material to specific cellular interfaces in tracheal fusion cells. We will investigate the formation, the dynamic behavior, and the regulation of SLs by Ca2+ signaling.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1348: Dynamic cellular interfaces: formation and function
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Stefan Luschnig