The in vivo role of RNA-binding proteins in neurogenesis, synapse formation and synaptic plasticity (A15*)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2018 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 118803580

In this new project, we aim to unravel how RBP-dependent asymmetric mRNA distribution in neuronal stem cells, neuronal progenitors and mature neurons influences neuronal differentiation, maturation and subsequent functional integration into existing neural circuits involving the hippocampus. In goal 1, we will investigate the role of Stau2 (and Pum2) in adult neurogenesis. In goal 2, we will unravel the in vivo role of Stau2 in synaptic plasticity and in learning and memory. Special emphasis will be given to the analysis of asymmetric RNA localization in neuronal stem cells and mature neurons.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 870: Assembly and Function of Neuronal Circuits in Sensory Processing
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Michael Kiebler