Regulation of myelinated axon structure by communication between axons and oligodendrocytes (A14*)

Subject Area Developmental Neurobiology
Term from 2018 to 2021
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 118803580
 

Project Description

Myelination by oligodendrocytes critically regulates structure, function, and survival of axons in the central nervous system through mechanisms that are not well understood. Here, we will use in vivo live cell imaging and genetic manipulations in zebrafish as model organism to elucidate the mechanisms by which axons and surrounding oligodendrocytes communicate to form, remodel and maintain myelinated axons and how this is controlled by cell intrinsic and extrinsic mechanisms.
DFG Programme Collaborative Research Centres
Subproject of SFB 870:  Assembly and Function of Neuronal Circuits in Sensory Processing
International Connection United Kingdom
Applicant Institution Ludwig-Maximilians-Universität München
Project Head Professor Tim Czopka, Ph.D.